D-Penicillamine Therapy for Rheumatoid Arthritis
نویسندگان
چکیده
منابع مشابه
D-penicillamine in rheumatoid arthritis.
D-penicillamine (D-pen) has gained wide-spread use as a potent suppressor of disease activity in rheumatoid arthritis (RA) and juvenile chronic arthritis (JCA). The drug has been established for antirheumatotd therapy on the basis o f a considerable number o f comparative clinical studies o f D-pen treatment versus placebo or other disease modifying antirheumatic drugs (DMARDs). Despite the pos...
متن کامل[D-penicillamine in rheumatoid arthritis].
In view of the claim that alclofenac has a specific antirheumatoid action a detailed biochemical study has been made over a 6-month period of 2 groups of patients with rheumatoid arthritis receiving either alclofenac or D-penicillamine for the first time. We found no biochemical evidence and little clinical evidence that alclofenac had a 'penicillamine-like' effect in rheumatoid arthritis.
متن کاملD-penicillamine withdrawal in rheumatoid arthritis.
Thirty-eight patients with rheumatoid arthritis in remission on penicillamine were entered into a prospective, randomised, placebo controlled study to determine the effects of gradual penicillamine withdrawal, to find a serological marker capable of predicting relapse, and to assess the effects of reintroduction of penicillamine. 80% of patients attempting gradual penicillamine withdrawal flare...
متن کاملAcquired sideroblastic anaemia associated with penicillamine therapy for rheumatoid arthritis.
Occupational exposure to various chemicals, including vinyl chloride, silica dust, epoxy resin, benzene, trichloroethylene, perchloroethylene, and other solvents, has been described as a potential provoking factor of systemic sclerosis (SSc) and scleroderma like disorders.' However, the precise contribution made by occupational environmental factors to the occurrence of scleroderma remains unkn...
متن کاملAcquired sideroblastic anaemia after aplastic anaemia caused by D-penicillamine therapy for rheumatoid arthritis.
A 68 year old man with rheumatoid arthritis developed marrow aplasia during D-penicillamine treatment. Recovery of granulopoiesis and erythropoiesis was ineffective with features of a secondary sideroblastic anaemia. Absence of megakaryopoiesis persisted. Therapeutic measures failed, and the patient finally died. These events illustrate a haematopoietic stem cell injury induced by D-penicillamine.
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ژورنال
عنوان ژورنال: Orthopedics & Traumatology
سال: 1977
ISSN: 1349-4333,0037-1033
DOI: 10.5035/nishiseisai.26.515